Tongxinluo Improves Apolipoprotein E-Deficient Mouse Heart Function
نویسندگان
چکیده
منابع مشابه
Tongxinluo Improves Apolipoprotein E-Deficient Mouse Heart Function
Background Our previous studies have shown that Tongxinluo (TXL), a compound Chinese medicine, can decrease myocardial ischemia-reperfusion injury, protect capillary endothelium function, and lessen cardiac ventricle reconstitution in animal models. The aim of this study was to illuminate whether TXL can improve hypercholesterolemia-impaired heart function by protecting artery endothelial funct...
متن کاملHeart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice.
BACKGROUND Elevated heart rate is associated with increased cardiovascular morbidity. We hypothesized that selective heart rate reduction may influence endothelial function and atherogenesis and tested the effects of the I(f) current inhibitor ivabradine in apolipoprotein E-deficient mice. METHODS AND RESULTS Male apolipoprotein E-deficient mice fed a high-cholesterol diet were treated with i...
متن کاملHeart rate reduction by ivabradine improves aortic compliance in apolipoprotein E-deficient mice.
BACKGROUND Impaired vascular compliance is associated with cardiovascular mortality. The effects of heart rate on vascular compliance are unclear. Therefore, we characterized effects of heart rate reduction (HRR) by I(f) current inhibition on aortic compliance and underlying molecular mechanisms in apolipoprotein E-deficient (ApoE(-)/(-)) mice. METHODS ApoE(-)/(-) mice fed a high-cholesterol ...
متن کاملHerpesvirus infection accelerates atherosclerosis in the apolipoprotein E-deficient mouse.
BACKGROUND Human herpesviruses have been implicated but not proven to be involved in the etiology of atherosclerosis. To determine whether there is a causal relationship, the effect of herpesvirus infection on the development of atherosclerosis was assessed in the apolipoprotein E-deficient (apoE-/-) mouse. METHODS AND RESULTS In the present study, 3- to 4-week-old apoE-/- mice were infected ...
متن کاملThyroid hormone receptor-α deletion decreases heart function and exercise performance in apolipoprotein E-deficient mice.
The deletion of thyroid hormone receptor-α (TRα) in atherosclerosis-prone apolipoprotein E-deficient (ApoE(-/-)) mice (ApoE(-/-)TRα(0/0)) accelerates the formation of atherosclerotic plaques without aggravation of hypercholesterolemia. To evaluate other predisposition risk factors to atherosclerosis in this model, we studied blood pressure (BP) and cardiac and vascular functions, as well as exe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chinese Medical Journal
سال: 2018
ISSN: 0366-6999
DOI: 10.4103/0366-6999.226063